Full Factorial Analysis of Mammalian and Avian Influenza Polymerase Subunits Suggests a Role of an Efficient Polymerase for Virus Adaptation
Identifieur interne : 001100 ( Main/Exploration ); précédent : 001099; suivant : 001101Full Factorial Analysis of Mammalian and Avian Influenza Polymerase Subunits Suggests a Role of an Efficient Polymerase for Virus Adaptation
Auteurs : Olive T. W. Li [République populaire de Chine] ; Michael C. W. Chan [République populaire de Chine] ; Cynthia S. W. Leung [République populaire de Chine] ; Renee W. Y. Chan [République populaire de Chine] ; Yi Guan [République populaire de Chine] ; John M. Nicholls [République populaire de Chine] ; Leo L. M. Poon [République populaire de Chine]Source :
- PLoS ONE [ 1932-6203 ] ; 2009.
Descripteurs français
- KwdFr :
- Adaptation biologique, Animaux, Chiens, Cytokines (métabolisme), Grippe chez les oiseaux (enzymologie), Gènes viraux, Humains, Lignée cellulaire, Luciferases (métabolisme), Mammifères (virologie), Mutation (génétique), Médiateurs de l'inflammation (métabolisme), Oiseaux, Passage en série, Poulets, Protéines virales (métabolisme), RNA replicase (métabolisme), Sous-unités de protéines (métabolisme), Sélection génétique, Virus de la grippe A (enzymologie), Virus de la grippe A (génétique).
- MESH :
- enzymologie : Grippe chez les oiseaux, Virus de la grippe A.
- génétique : Mutation, Virus de la grippe A.
- métabolisme : Cytokines, Luciferases, Médiateurs de l'inflammation, Protéines virales, RNA replicase, Sous-unités de protéines.
- virologie : Mammifères.
- Adaptation biologique, Animaux, Chiens, Gènes viraux, Humains, Lignée cellulaire, Oiseaux, Passage en série, Poulets, Sélection génétique.
English descriptors
- KwdEn :
- Adaptation, Biological, Animals, Birds, Cell Line, Chickens, Cytokines (metabolism), Dogs, Genes, Viral, Humans, Inflammation Mediators (metabolism), Influenza A virus (enzymology), Influenza A virus (genetics), Influenza in Birds (enzymology), Luciferases (metabolism), Mammals (virology), Mutation (genetics), Protein Subunits (metabolism), RNA Replicase (metabolism), Selection, Genetic, Serial Passage, Viral Proteins (metabolism).
- MESH :
- chemical , metabolism : Cytokines, Inflammation Mediators, Luciferases, Protein Subunits, RNA Replicase, Viral Proteins.
- enzymology : Influenza A virus, Influenza in Birds.
- genetics : Influenza A virus, Mutation.
- virology : Mammals.
- Adaptation, Biological, Animals, Birds, Cell Line, Chickens, Dogs, Genes, Viral, Humans, Selection, Genetic, Serial Passage.
Abstract
Amongst all the internal gene segments (PB2. PB1, PA, NP, M and NS), the avian PB1 segment is the only one which was reassorted into the human H2N2 and H3N2 pandemic strains. This suggests that the reassortment of polymerase subunit genes between mammalian and avian influenza viruses might play roles for interspecies transmission. To test this hypothesis, we tested the compatibility between PB2, PB1, PA and NP derived from a H5N1 virus and a mammalian H1N1 virus. All 16 possible combinations of avian-mammalian chimeric viral ribonucleoproteins (vRNPs) were characterized. We showed that recombinant vRNPs with a mammalian PB2 and an avian PB1 had the strongest polymerase activities in human cells at all studied temperature. In addition, viruses with this specific PB2-PB1 combination could grow efficiently in cell cultures, especially at a high incubation temperature. These viruses were potent inducers of proinflammatory cytokines and chemokines in primary human macrophages and pneumocytes. Viruses with this specific PB2-PB1 combination were also found to be more capable to generate adaptive mutations under a new selection pressure. These results suggested that the viral polymerase activity might be relevant for the genesis of influenza viruses of human health concern.
Url:
DOI: 10.1371/journal.pone.0005658
PubMed: 19462010
PubMed Central: 2680953
Affiliations:
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W." last="Li">Olive T. W. Li</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Michael C W" sort="Chan, Michael C W" uniqKey="Chan M" first="Michael C. W." last="Chan">Michael C. W. Chan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Leung, Cynthia S W" sort="Leung, Cynthia S W" uniqKey="Leung C" first="Cynthia S. W." last="Leung">Cynthia S. W. Leung</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Chan, Renee W Y" sort="Chan, Renee W Y" uniqKey="Chan R" first="Renee W. Y." last="Chan">Renee W. Y. Chan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Nicholls, John M" sort="Nicholls, John M" uniqKey="Nicholls J" first="John M." last="Nicholls">John M. Nicholls</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Pathology, The University of Hong Kong, Hong Kong SAR, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Pathology, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author><author><name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L. M." last="Poon">Leo L. M. Poon</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR, China</addr-line></nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Emerging Infectious Diseases, Department of Microbiology, The University of Hong Kong, Hong Kong SAR</wicri:regionArea><wicri:noRegion>Hong Kong SAR</wicri:noRegion></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Biological</term><term>Animals</term><term>Birds</term><term>Cell Line</term><term>Chickens</term><term>Cytokines (metabolism)</term><term>Dogs</term><term>Genes, Viral</term><term>Humans</term><term>Inflammation Mediators (metabolism)</term><term>Influenza A virus (enzymology)</term><term>Influenza A virus (genetics)</term><term>Influenza in Birds (enzymology)</term><term>Luciferases (metabolism)</term><term>Mammals (virology)</term><term>Mutation (genetics)</term><term>Protein Subunits (metabolism)</term><term>RNA Replicase (metabolism)</term><term>Selection, Genetic</term><term>Serial Passage</term><term>Viral Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adaptation biologique</term><term>Animaux</term><term>Chiens</term><term>Cytokines (métabolisme)</term><term>Grippe chez les oiseaux (enzymologie)</term><term>Gènes viraux</term><term>Humains</term><term>Lignée cellulaire</term><term>Luciferases (métabolisme)</term><term>Mammifères (virologie)</term><term>Mutation (génétique)</term><term>Médiateurs de l'inflammation (métabolisme)</term><term>Oiseaux</term><term>Passage en série</term><term>Poulets</term><term>Protéines virales (métabolisme)</term><term>RNA replicase (métabolisme)</term><term>Sous-unités de protéines (métabolisme)</term><term>Sélection génétique</term><term>Virus de la grippe A (enzymologie)</term><term>Virus de la grippe A (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cytokines</term><term>Inflammation Mediators</term><term>Luciferases</term><term>Protein Subunits</term><term>RNA Replicase</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Grippe chez les oiseaux</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Influenza A virus</term><term>Influenza in Birds</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Influenza A virus</term><term>Mutation</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Mutation</term><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cytokines</term><term>Luciferases</term><term>Médiateurs de l'inflammation</term><term>Protéines virales</term><term>RNA replicase</term><term>Sous-unités de protéines</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Mammifères</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Mammals</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adaptation, Biological</term><term>Animals</term><term>Birds</term><term>Cell Line</term><term>Chickens</term><term>Dogs</term><term>Genes, Viral</term><term>Humans</term><term>Selection, Genetic</term><term>Serial Passage</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adaptation biologique</term><term>Animaux</term><term>Chiens</term><term>Gènes viraux</term><term>Humains</term><term>Lignée cellulaire</term><term>Oiseaux</term><term>Passage en série</term><term>Poulets</term><term>Sélection génétique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Amongst all the internal gene segments (PB2. PB1, PA, NP, M and NS), the avian PB1 segment is the only one which was reassorted into the human H2N2 and H3N2 pandemic strains. This suggests that the reassortment of polymerase subunit genes between mammalian and avian influenza viruses might play roles for interspecies transmission. To test this hypothesis, we tested the compatibility between PB2, PB1, PA and NP derived from a H5N1 virus and a mammalian H1N1 virus. All 16 possible combinations of avian-mammalian chimeric viral ribonucleoproteins (vRNPs) were characterized. We showed that recombinant vRNPs with a mammalian PB2 and an avian PB1 had the strongest polymerase activities in human cells at all studied temperature. In addition, viruses with this specific PB2-PB1 combination could grow efficiently in cell cultures, especially at a high incubation temperature. These viruses were potent inducers of proinflammatory cytokines and chemokines in primary human macrophages and pneumocytes. Viruses with this specific PB2-PB1 combination were also found to be more capable to generate adaptive mutations under a new selection pressure. These results suggested that the viral polymerase activity might be relevant for the genesis of influenza viruses of human health concern.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fouchier, Ra" uniqKey="Fouchier R">RA Fouchier</name></author><author><name sortKey="Munster, V" uniqKey="Munster V">V Munster</name></author><author><name sortKey="Wallensten, A" uniqKey="Wallensten A">A Wallensten</name></author><author><name sortKey="Bestebroer, Tm" uniqKey="Bestebroer T">TM Bestebroer</name></author><author><name sortKey="Herfst, S" uniqKey="Herfst S">S Herfst</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Murphy, Br" uniqKey="Murphy B">BR Murphy</name></author><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Webster, Rg" uniqKey="Webster R">RG Webster</name></author><author><name 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W." last="Li">Olive T. W. Li</name></noRegion><name sortKey="Chan, Michael C W" sort="Chan, Michael C W" uniqKey="Chan M" first="Michael C. W." last="Chan">Michael C. W. Chan</name><name sortKey="Chan, Renee W Y" sort="Chan, Renee W Y" uniqKey="Chan R" first="Renee W. Y." last="Chan">Renee W. Y. Chan</name><name sortKey="Guan, Yi" sort="Guan, Yi" uniqKey="Guan Y" first="Yi" last="Guan">Yi Guan</name><name sortKey="Leung, Cynthia S W" sort="Leung, Cynthia S W" uniqKey="Leung C" first="Cynthia S. W." last="Leung">Cynthia S. W. Leung</name><name sortKey="Nicholls, John M" sort="Nicholls, John M" uniqKey="Nicholls J" first="John M." last="Nicholls">John M. Nicholls</name><name sortKey="Poon, Leo L M" sort="Poon, Leo L M" uniqKey="Poon L" first="Leo L. M." last="Poon">Leo L. M. Poon</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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